ADME/Tox: How Low Can You Go?
and How Do You Recover?
Dr.
Christopher A. Lipinski, Ph.D. Adjunct Senior Research
Fellow - Pfizer Global R & D Are ever-worsening ADME/Tox problems
sinking you?
Dr. Lipinski will examine the causes and cures of these
issues, helping you understand:
Garbage In-Garbage Out
Chemistry—How poor choices & screening can
doom a project from the start
How to filter out difficult
problems in Medicinal Chemistry SAR
Lead-like vs. Drug-like
library issues
Why a Genomics person can
be a Chemist’s Best Friend—Solving classic
chemistry disconnects together
How HTS screening &
compound management can reduce your ADME/Tox woes &
increase productivity
Why ADME recovery is underway
in large Pharma, but Tox is the “slowest ship
in the convoy”
Dr. Lipinski retired from the position of Senior Research
Fellow in the Exploratory Medicinal Sciences Dept. at
the Pfizer Global Research & Development Groton Laboratories
in June 2002 after a distinguished 32-year career. His
lab provided experimental solubility measurements on medicinal
compounds, and championed a computationally pragmatic,
chemistry end user-oriented approach to oral bioactivity
improvement. He is a member of numerous scientific organizations,
advisory boards, editorial boards for scientific journals,
and is an adjunct faculty member at Connecticut College
in New London, CT. Dr. Lipinski is the recipient of the
American
Chemical Society 2004 Medicinal Chemistry Award.