Predicting Drug Disposition via Application of BCS:
Transport/Absorption/Elimination Interplay and BDDCS
Dr. Leslie Benet, Ph.D.
Professor, Department of Biopharmaceutical Sciences, UCSF
Dr. Benet will examine the utility of the Biopharmaceutics Classification System (BCS) and help you understand:
- The Biopharmaceutics Classification System (BCS) - A system for predicting in vivo performance of drug products from in vitro measurements
- Slight modifications of such a Classification system can be useful in predicting
- Routes of drug elimination
- The effects of efflux and absorptive transporters on oral drug absorption
- When transporter-enzyme interplay will yield clinically significant effects
- Transporter effects on post-absorptive systemic drug concentrations
- Drug-drug interaction potential via the relationship to enzyme-transporter interplay
Dr. Benet, Professor, Department of Biopharmaceutical Sciences, UCSF and Founder of AvMax, Inc., received honorary doctorates from five Universities: Uppsala (1987), Leiden (1995), Illinois at Chicago and PCP&S (1997) and Long Island (1999). During 1986, Dr. Benet was a founder and first President of AAPS. In 1987 he was elected to membership in the Institute of Medicine of the U.S. National Academy of Sciences. His many awards include: AAPS Distinguished Pharmaceutical Scientist (1989); AACP Volwiler Research Achievement (1991); ASCPT Rawls-Palmer Award (1995); APhA Higuchi Research Prize (2000); AAPS Wurster Award in Pharmaceutics (2000); FIP Høst-Madsen Medal (2001); recognized among the 250 most cited pharmacologists, world-wide (2003); PSWC Research Achievement and CRS Career Achievement in Oral Drug Delivery (2004). His research interests, more than 450 publications and 10 patents are in the areas of pharmacokinetics, biopharmaceutics, drug delivery and pharmacodynamics.